CONTEMPORARY CONSERVATION DOCTRINE - ISSUES OF CONSERVATION PROTECTION ZONES BASED ON THE EXAMPLE OF TARNOBRZEG

Contemporary conservation doctrine - issues of conservation protection zones based on the example of Tarnobrzeg

The paper concerns the issue of conservation protection covering the researched areas of Tarnobrzeg.In particular, it describes the principles of delimiting areas and grounds for narrowing the previously adopted preservation zones.Based on reliable analyses, one presents the fundamentals, which result in the necessity of modifying and verifying the

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The UCHL5 inhibitor b-AP15 overcomes cisplatin resistance via suppression of cancer stemness in urothelial carcinoma

Urothelial carcinoma (UC) comprises the majority of bladder cancers.Standard platinum-based chemotherapy has a response rate of approximately 50%, but drug resistance develops after short-term treatment.Deubiquitinating (DUB) enzyme inhibitors increase protein polyubiquitination and endoplasmic reticulum (ER) stress, which might further suppress ca

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